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spoke to Pompeo on her lunch break earlier this week to talk about Meredith's future, why ageism is alive and well in Hollywood, and what she and Meredith is savagely attacked by a patient in the mid-season premiere.
How does this twist compare to some of the many other big twists or shockers on the show?
And lastly, who's a bigger bitch to work with: Katherine Heigl or Isaiah Washington?
"I think a lot of people were really upset about his departure, which is super-understandable, but I think the change is part of the reason why the show goes on so long.
I think people tune in to see, ' What does the show look like now? I think they get so upset about the change, but change is precisely what everyone always needs to sort of get to the next place."Watch the video above.
(He isn't the only star on Grey's to get the boot from the show due to personal differences.
Other former stars include Katherine Heigl and Isaiah Washington.
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is an American actor and race car driver, best known for his role as neurosurgeon Derek "Mc Dreamy" Shepherd in Grey's Anatomy.